![]() As in a race against time, the disease should be promptly stopped there, to avoid the multiplication and spreading of worse, drug‐resistant parasites (Nature, 2018). In parallel, we are constantly witnessing cases of large local resurgence, with hot spots, such as the Greater Mekong region. ![]() ![]() ![]() The increased mobility, globalization, and immigration phenomena have caused some resurgence of malaria also in Western countries, where it was eradicated in the last century. 228 million new cases and 405,000 deaths in 2018 were estimated (WHO, 2018). Nonspecific attraction of untreated RBCs was not observed in the same time interval.ĭespite references to malaria are present throughout recorded history, since the very beginning of human civilization, 3.2 billion people are still at risk for malaria according to the World Health Organization (WHO). Sample preparation requires only a 1:10 volume dilution of whole blood, previously treated with heparin, in a phosphate‐buffered solution. By proper agitation, the capture efficiency reached 85% after just 5 min. Using a model of infected RBCs, that is, erythrocytes with methemoglobin, we obtained a capture efficiency of about 70% after 10 min in static conditions. A matrix of nickel posts fabricated in a silicon chip placed face down is aimed at attracting infected cells, while healthy cells sediment on a glass slide under the action of gravity. The method relies on the positive magnetic susceptibility of infected RBCs with respect to blood plasma. In this study, we characterize systematically an easy‐to‐operate lab‐on‐chip, designed for the magnetophoretic capture of malaria‐infected red blood cells (RBCs). ![]() The search for new rapid diagnostic tests for malaria is a priority for developing an efficient strategy to fight this endemic disease, which affects more than 3 billion people worldwide. ![]()
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